nitro-Grela
Chemical name:
(1,3-dimesitylimidazolidin-2-ylidene)dichloro(2-isopropoxy-5-nitrobenzylidene)ruthenium(II)
Product number:
AS2032
CAS number:
502964-52-5
Patent number:
PCT/EP2003/011222
Universal catalyst which provides good results in a wide spectrum of transformations. High selectivity in cross metathesis (CM) reactions between type 1 olefins (rapid homodimerization, homodimers consumable) and an electron deficient partner, but gives lower efficiency (defined as Turnover Number, TON) than nitro-Grela-SIPr in this type of reactions. More efficient than other catalysts presented herein in reactions with sterically demanding substrates. Comparison with competing products:
– RCM: It is possible to perform the reaction at lower temperature (0 °C). Hoveyda-Grubbs II require higher temperature.
– En-yn: using nitro-Grela gives higher conversion with 2.5 times lower loading catalyst than Hoveyda-Grubbs,
– CM: nitro-Grela allows to perform reaction at lower temperature, with lower loading than Grubbs-II and Hoveyda-Grubbs II. The desired products are obtained with higher selectivity.
Distributors
Chemical properties
Chemical formula:
C31H37Cl2N3O3Ru
Molecular weight: 671.62 g/mol
Physical state: powder
Color: green
Questions about the product?
EUROPE
Monika Kulinicz
Sales and Technical Support
monika.kulinicz@apeiron-synthesis.com
Tel.: (+48) 71 798 56 23
NORTH AMERICA
Grażyna Szymańska, PhD
Global Business Development
grazyna.szymanska@apeiron-synthesis.com
Cell: (+1) 781 608 5859
Handling information
High stability allows catalyst handling on air.
Storage information
Long-term storage (>1 week): Store under inert gas in a cold place (recommended temp. 2 – 8 oC).
Short-term storage (<1 week): Store under inert gas at ambient temperature.
Applications
Reference list
- PCT/EP2003/011222
- K. Grela, S. Harutyunyan, A. Michrowska “A New Highly Efficient Ruthenium Catalyst for Metathesis Reaction” Angew. Chem. Int. Ed., 41, 4038 – 4040, (2002).
- K. Grela, A. Michrowska, M. Bieniek, M. Kim, R. Klajn “Cross-metathesis reaction of vinyl sulfones and sulfoxides” Tetrahedron, 59, 4525 – 4531, (2003).