Szczepaniak et al. have reported a study on quenching and effective removal of copper residues after Cu/TEMPO-catalyzed aerobic alcohol oxidation (Stahl oxidation) and atom transfer radical polymerization (ATRP). The article was published in Chemical Science and the study is based on Apeiron’s commercially available product – SnatchCat (1,4-bis(3-isocyanopropyl)piperazine).
The results presented in this study showed that SnatchCat can be used as a highly efficient copper scavenger in the purification of Cu/TEMPO alcohol aerobic oxidation products, being able to purify both small and macromolecules. It can also be used for polymers purification produced by Cu-catalyzed ATRP. Referring to both analyzed reactions, the addition of SnatchCat followed by the application of simple purification protocols resulted in very low Cu content below 5 ppm in isolated aldehydes as well as in polymers, even after ATRP with high catalyst loading.
Another advantage of our product exhibited therein, is that it rapidly stops copper-mediated reactions, facilitating the kinetic studies and reaction design or copper removal by filtration. Moreover, the authors also demonstrated that SnatchCat could be successfully used to prevent side reactions. It completely prevented the Glaser coupling under oxidative conditions occurring during polymers workup.
The cytotoxicity of Apeiron’s scavenger and quenching agent has also been examined. Although isocyanide proved to be moderately cytotoxic, it could be easily neutralized by acid hydrolysis.
If you would like to learn more about the applicability of SnatchCat in two fundamental reactions catalyzed by copper complexes, please refer to the whole open access article here.
Interesting application of Apeiron’s catalyst – FixCat has been reported by Bizzarri et al. in the new article published in ‘Catalysts’. The article entitled ‘Synthesis of Stilbene and Chalcone Inhibitors of Inﬂuenza A Virus by SBA-15 Supported Hoveyda-Grubbs Metathesis’ proves that FixCat/SBA-15 is an efficient heterogenous catalyst for the synthesis of stilbene and chalcone derivatives with biological activity against Influenza A virus via different types of olefin metathesis reactions.
Despite of the catalyst immobilization on eco-compatible and stable support, the activity and selectivity of FixCat/SBA-15 was at a comparable level to the homogenous counterpart in all of the types of metathesis reactions tested. The heterogenized catalyst was stable retaining its reactivity during the recycles with satisfactory substrate conversion and product yielding.
Noteworthy, antiviral activity exhibited by the derivatives obtained had significant IC50 values and mainly involved the early stage of the virus-replication life-cycle, such as transcription or viral uncoating.
Demonstrated stilbene and chalcone inhibitors could be an alternative to currently available antiviral compounds against influenza A virus.
The full version of the aforementioned article is available online here.
Dear customers and business partners,
Apeiron Synthesis S.A. would like to inform you that for the sake of the protection of our employees’ health and safety and in order to minimize the risk of Sars-CoV-2 spreading, most of our team is currently moving to the remote work system.
Due to the above, the availability of phone contact with our team may be limited. If possible, we recommend choosing an email contact. However, we would like to assure that we fully understand the needs of our customers and we endeavor to keep our operations running smoothly. All orders are still being accepted and processed normally. We also encourage you to submit technical and offer inquiries – our representatives are at our customer’s disposal to assist them in any matter.
We continue to monitor the situation and will notify you of any significant changes affecting Apeiron’s operation.
Moreover, as a responsible company, we must take action and lead by example to help our local community. Apeiron is actively participating in the fight against ‘coronavirus’ by donating personal protection equipment to local hospitals.
We wish you continued good health and we believe that soon we will overcome this crisis together.
Michał Bieniek PhD, CEO
On the 27th February, Apeiron’s team consisting of: Joanna Drygajlo-Glever – Sales Manager, Agnieszka Roszyk – Key Account Manager and Monika Kulinicz – Sales Representative will participate in the 4th edition of ECP.
European Chemistry Partnering is an exceptionally well-organized event, a dynamic and extensive networking platform for companies focused on innovation-driven solutions in the chemical industry. ECP brings together start-ups, industry members and investors at the same time and lays strong emphasis on business match-making. This is an excellent opportunity to enhance your visibility on the European market, establish new connections, develop and expand your network.
Our delegation will be delighted to discuss with you the potential of our leading edge olefin metathesis technology.
If you are interested in a face-to-face meeting, please feel free to reach out to us through the online meeting scheduling system, visit our booth or find us during the Pre-Evening Get-Together!
From 11-13 February, Apeiron Synthesis will be exhibiting at Specialty & Custom Chemicals America in Fort Worth, TX, known as the ‘City of Cowboys and Culture’.
The event is focused on the chemical products and technologies that find applications in industrial chemical markets such as: Pharmaceuticals, Flavors & Fragrances, Polymers, Composites, Agriculture, Renewables.
If you also attend the show, we will be pleased to tell you more about how Apeiron’s olefin metathesis catalysts could add value to your processes in these fine and specialty chemical end-uses. Andrzej Tracz, Senior Scientist and Monika Kulinicz, Sales Representative look forward to seeing you at our stand No. 711!