SBA-15 supported FixCat used for the metathetic synthesis of stilbene and chalcone inhibitors of Influenza A virus.

Interesting application of Apeiron’s catalyst – FixCat has been reported by Bizzarri et al. in the new article published in ‘Catalysts’. The article entitled ‘Synthesis of Stilbene and Chalcone Inhibitors of Influenza A Virus by SBA-15 Supported Hoveyda-Grubbs Metathesis’ proves that FixCat/SBA-15 is an efficient heterogenous catalyst for the synthesis of stilbene and chalcone derivatives with biological activity against Influenza A virus via different types of olefin metathesis reactions.

Despite of the catalyst immobilization on eco-compatible and stable support, the activity and selectivity of FixCat/SBA-15 was at a comparable level to the homogenous counterpart in all of the types of metathesis reactions tested. The heterogenized catalyst was stable retaining its reactivity during the recycles with satisfactory substrate conversion and product yielding.
Noteworthy, antiviral activity exhibited by the derivatives obtained had significant IC50 values ​​and mainly involved the early stage of the virus-replication life-cycle, such as transcription or viral uncoating.

Demonstrated stilbene and chalcone inhibitors could be an alternative to currently available antiviral compounds against influenza A virus.

The full version of the aforementioned article is available online here.


COVID-19 Statement – We are still here for you!

Dear customers and business partners,

Apeiron Synthesis S.A. would like to inform you that for the sake of the protection of our employees’ health and safety and in order to minimize the risk of Sars-CoV-2 spreading, most of our team is currently moving to the remote work system.

Due to the above, the availability of phone contact with our team may be limited. If possible, we recommend choosing an email contact. However, we would like to assure that we fully understand the needs of our customers and we endeavor to keep our operations running smoothly. All orders are still being accepted and processed normally. We also encourage you to submit technical and offer inquiries – our representatives are at our customer’s disposal to assist them in any matter.

We continue to monitor the situation and will notify you of any significant changes affecting Apeiron’s operation.

Moreover, as a responsible company, we must take action and lead by example to help our local community. Apeiron is actively participating in the fight against ‘coronavirus’ by donating personal protection equipment to local hospitals.

We wish you continued good health and we believe that soon we will overcome this crisis together.

Stay safe!

Michał Bieniek PhD, CEO


Meet us at the 4th European Chemistry Partnering!

On the 27th February, Apeiron’s team consisting of: Joanna Drygajlo-Glever – Sales Manager, Agnieszka Roszyk – Key Account Manager and Monika Kulinicz – Sales Representative will participate in the 4th edition of ECP.

European Chemistry Partnering is an exceptionally well-organized event, a dynamic and extensive networking platform for companies focused on innovation-driven solutions in the chemical industry. ECP brings together start-ups, industry members and investors at the same time and lays strong emphasis on business match-making. This is an excellent opportunity to enhance your visibility on the European market, establish new connections, develop and expand your network.

Our delegation will be delighted to discuss with you the potential of our leading edge olefin metathesis technology.

If you are interested in a face-to-face meeting, please feel free to reach out to us through the online meeting scheduling system, visit our booth or find us during the Pre-Evening Get-Together!


Will you be attending Specialty & Custom Chemicals America 2020?

From 11-13 February, Apeiron Synthesis will be exhibiting at Specialty & Custom Chemicals America in Fort Worth, TX, known as the ‘City of Cowboys and Culture’.

The event is focused on the chemical products and technologies that find applications in industrial chemical markets such as:  Pharmaceuticals, Flavors & Fragrances, Polymers, Composites, Agriculture, Renewables.

If you also attend the show, we will be pleased to tell you more about how Apeiron’s olefin metathesis catalysts could add value to your processes in these fine and specialty chemical end-uses. Andrzej Tracz, Senior Scientist and Monika Kulinicz, Sales Representative look forward to seeing you at our stand No. 711!


Will you attend the ACS Fall 2019 National Meeting and Exposition in San Diego Convention Center between August 25-29?

If so, come and meet our team at booth 2437, where our Senior Scientist Andrzej Tracz and Sales Representative Monika Kulinicz will be delighted to discuss our unique solutions, extensive product portfolio and services provided in the field of process oriented olefin metathesis.

Drop by and see how our technology can make your business more profitable and sustainable!

We look forward to meeting you in San Diego!

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