5. Developement of an alternative pathways

Industrial Validation: Alternative pathways towards a troublesome small heterocyclic molecule were investigated by Apeiron partner. One of the most promising synthetic routs entailed a three-step process with RCM representing the ultimate reaction in the sequence. Customer’s internal efforts failed to deliver the target molecule in the olefin metathesis-based pathway. One week proof of concept study at Apeiron confirmed the process viability. Within additional two months of optimization efforts Apeiron successfully obtained the requested product with concentration increased three times and catalyst costs reduced more than 30 times in respect to the customer’s guidelines.

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