nitro-Grela

Chemical name:

(1,3-dimesitylimidazolidin-2-ylidene)dichloro(2-isopropoxy-5-nitrobenzylidene)ruthenium(II)

Product number:

AS2032

CAS number:

502964-52-5

Patent number:

PCT/EP2003/011222

Universal catalyst which provides good results in a wide spectrum of transformations. High selectivity in cross metathesis (CM) reactions between type 1 olefins (rapid homodimerization, homodimers consumable) and an electron deficient partner, but gives lower efficiency (defined as Turnover Number, TON) than nitro-Grela-SIPr in this type of reactions. More efficient than other catalysts presented herein in reactions with sterically demanding substrates. Comparison with competing products:
– RCM: It is possible to perform the reaction at lower temperature (0 °C). Hoveyda-Grubbs II require higher temperature.
– En-yn: using nitro-Grela gives higher conversion with 2.5 times lower loading catalyst than Hoveyda-Grubbs,
– CM: nitro-Grela allows to perform reaction at lower temperature, with lower loading than Grubbs-II and Hoveyda-Grubbs II. The desired products are obtained with higher selectivity.

Distributors
Chemical properties

Chemical formula: 

C31H37Cl2N3O3Ru

Molecular weight: 671.62 g/mol

Physical state: powder

Color: green

Questions about the product?
EUROPE

Monika Kulinicz

Sales and Technical Support

monika.kulinicz@apeiron-synthesis.com

Tel.: (+48) 71 798 56 21

NORTH AMERICA

Grazyna Szymanska, PhD

Global Business Development

grazyna.szymanska@apeiron-synthesis.com

Cell: (+1) 781 608 5859

Handling information

High stability allows catalyst handling on air.

Storage information

Long-term storage (>1 week): Store under inert gas in a cold place (recommended temp. 2 – 8 oC).

Short-term storage (<1 week): Store under inert gas at ambient temperature.

Applications

Reference list

1. PCT/EP2003/011222;

2. K. Grela, S. Harutyunyan, A. Michrowska “A New Highly Efficient Ruthenium Catalyst for Metathesis Reaction” Angew. Chem. Int. Ed., 41, 4038 – 4040, (2002);

3. Grela, K.; Michrowska, A.; Bieniek, M.; Kim, M.; Klajn, R. “Cross-metathesis reaction of vinyl sulfones and sulfoxides” Tetrahedron 2003, 59, 4525-4531.