Industrial Validation: A large specialty chemicals partner wanted to reduce manufacturing costs for a product using a new, more efficient process that incorporated a RCM step. Internal efforts, due to the high dilution required and unacceptably high catalyst loadings, led to unsatisfactory results as the catalyst cost for a production run was projected to be higher than the market price for the final product. Following four months of optimization, Apeiron chemists provided the partner an efficient process with 6 times lower catalyst loadings than specified (500 times lower than the original process). Additionally, reaction concentration and yields were increased four- and twofold respectively. Reduction of catalyst costs exceeded the customer’s expectations reaching 17 euro per 1 kg of the product.